在线提供 19 October 2023
The repair and regeneration of bone defects are highly challenging
orthopedic problems. Recently, Mg-based implants have gained popularity
due to their unique biodegradation and elastic modulus similar to that
of human bone. The aim of our study is to develop a magnesium alloy with
a controllable degradation that can closely match bone tissue to help
injuries heal in vivo and avoid cytotoxicity caused by a sudden
increase in ion concentration. In this study, we prepared and modified
Mg-3 Zn, Mg-3Zn-1Y, and Mg-2Zn-1Mn by hot extrusion, and used
Mg-2.5Y-2.5Nd was as a control. We then investigated the effect of
additions of Y and Mn on alloys’ properties. Our results show that Mn
and Y can improve not only compression strength but also corrosion
resistance. The alloy Mg-2Zn-1Mn demonstrated good cytocompatibility in vitro, and for this reason we selected it for implantation in vivo.
The degraded Mg-2Zn-1Mn implanted a bone defect area did not cause
obvious rejection and inflammatory reaction, and the degradation
products left no signs of damage to the heart, liver, kidney, or brain.
Furthermore, we find that Mg-2Zn-1Mn can promote an osteoinductive
response in vivo and the formation of bone regeneration.
